POLH Protein (Myc-DYKDDDDK Tag)
This Recombinant POLH protein is expressed in HEK-293 Cells.
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Catalog No. ABIN2729308
$1,112.40
Plus shipping costs $50.00, if applicable $20.00 dry ice
20 μg
Shipping to:
United States
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Quick Overview for POLH Protein (Myc-DYKDDDDK Tag) (ABIN2729308)
Target
See all POLH Proteins
POLH
(Polymerase (DNA Directed), eta (POLH))
Protein Type
Recombinant
Origin
Human
Source
HEK-293 Cells
Application
Antibody Production (AbP), Standard (STD)
Purity
> 80 % as determined by SDS-PAGE and Coomassie blue staining
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Purification tag / Conjugate
- This POLH protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human POLH / RAD30 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Polymerase (DNA Directed), eta (POLH) (AA 1-414) protein (GST tag)
POLH Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- POLH (Polymerase (DNA Directed), eta (POLH))
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Alternative Name
- Polh,rad30
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Background
- This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
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Molecular Weight
- 78.2 kDa
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NCBI Accession
- NP_006493
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Pathways
- DNA Damage Repair
Target
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