POT1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
(2 references)Quick Overview for POT1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2729370)
Target
See all POT1 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- Transcript Variant 1
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Purification tag / Conjugate
- This POT1 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human POT1 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Protection of Telomeres 1 (POT1) (AA 1-640) protein (His tag)
custom-made POT1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Protection of Telomeres 1 (POT1) (AA 1-634) protein (His tag)custom-made POT1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Protection of Telomeres 1 (POT1) (AA 1-95) protein (GST tag)POT1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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: "An H2A Histone Isotype, H2ac, Associates with Telomere and Maintains Telomere Integrity." in: PLoS ONE, Vol. 11, Issue 5, pp. e0156378, (2016) (PubMed).
: "The OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs." in: Biochimie, Vol. 115, pp. 17-27, (2015) (PubMed).
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- POT1 (Protection of Telomeres 1 (POT1))
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Alternative Name
- Pot1
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Background
- This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
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Molecular Weight
- 71.3 kDa
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NCBI Accession
- NP_056265
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Pathways
- Cell Division Cycle, Telomere Maintenance
Target
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