PTPN12 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
Quick Overview for PTPN12 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2730111)
Target
See all PTPN12 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- Transcript Variant 1
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Purification tag / Conjugate
- This PTPN12 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human PTPN12 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Protein Tyrosine Phosphatase G1 (PTPN12) (AA 1-780) protein (GST tag)
PTPN12 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Protein Tyrosine Phosphatase G1 (PTPN12) (AA 2-300) protein (His-IF2DI Tag)PTPN12 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))
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Alternative Name
- Ptpn12
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Background
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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Molecular Weight
- 87.9 kDa
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NCBI Accession
- NP_002826
Target
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