Retinoblastoma Binding Protein 4 Protein (RBBP4) (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2730578

Recombinant Retinoblastoma Binding Protein 4 protein expressed in HEK-293 Cells.

Quick Overview for Retinoblastoma Binding Protein 4 Protein (RBBP4) (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2730578)

Target: Retinoblastoma Binding Protein 4 (RBBP4)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Protein Characteristics: Transcript Variant 1

Purification tag / Conjugate: This Retinoblastoma Binding Protein 4 protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human RBBP4 / RBAP48 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: Retinoblastoma Binding Protein 4 (RBBP4)

Alternative Name: Rbbp4,rbap48

Background: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 47.5 kDa

NCBI Accession: NP_005601

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases, Stem Cell Maintenance, Chromatin Binding, Protein targeting to Nucleus