SHC1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
Quick Overview for SHC1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag) (ABIN2731993)
Target
See all SHC1 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- Transcript Variant 2
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Purification tag / Conjugate
- This SHC1 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human SHC1 / SHC (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 161-474) protein (His tag)
SHC1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 1-474) protein (His tag)SHC1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
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Alternative Name
- Shc1,shc
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Background
- This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
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Molecular Weight
- 51.5 kDa
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NCBI Accession
- NP_003020
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Pathways
- RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
Target
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