SPG20 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2732507

Recombinant SPG20 protein expressed in HEK-293 Cells.

Quick Overview for SPG20 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2732507)

Target: SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Protein Characteristics: Transcript Variant 1

Purification tag / Conjugate: This SPG20 protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human Spartin / SPG20 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))

Alternative Name: Spartin,spg20

Background: This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).

Molecular Weight: 72.7 kDa

NCBI Accession: NP_055902

Pathways: Regulation of Cell Size, SARS-CoV-2 Protein Interactome