STAT5B Protein (Myc-DYKDDDDK Tag)
Quick Overview for STAT5B Protein (Myc-DYKDDDDK Tag) (ABIN2732827)
Target
See all STAT5B ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This STAT5B protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human STAT5B protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-786) protein (His tag)
custom-made STAT5B Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-787) protein (His tag)custom-made STAT5B Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-390) protein (GST tag)STAT5B Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-321) protein (His-IF2DI Tag)STAT5B Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))
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Alternative Name
- Stat5b
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Background
- The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
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Molecular Weight
- 89.7 kDa
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NCBI Accession
- NP_036580
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Pathways
- JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation
Target
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