TBL1X Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2733297

This Recombinant TBL1X protein is produced in HEK-293 Cells.

Quick Overview for TBL1X Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2733297)

Target: TBL1X (Transducin (Beta)-Like 1X-Linked (TBL1X))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Protein Characteristics: Transcript Variant 1

Purification tag / Conjugate: This TBL1X protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human TBL1 / TBL1X (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: TBL1X (Transducin (Beta)-Like 1X-Linked (TBL1X))

Alternative Name: Tbl1,tbl1x

Background: The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.

Molecular Weight: 62.3 kDa

NCBI Accession: NP_005638

Pathways: Sensory Perception of Sound, Regulation of Lipid Metabolism by PPARalpha