Estrogen Receptor alpha Protein

Catalog No. ABIN2746587

Product Details

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Protein Type: Recombinant

Origin: Human, Rat

Source: Escherichia coli (E. coli)

Application: Western Blotting (WB), Positive Control (PC)

Purpose: Purified Protein in ready-to-use SDS sample buffer.

Purification: Purified Protein

Application Details

Application Notes: The sample is in ready-to-use buffer for application in SDS-PAGE and Western blotting.

Comment:

Synonyms: ER-alpha,ESR1, Estradiol receptor antibody, Nuclear receptor subfamily 3 group A member 1 antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: For 5 applications, volume varies from 100-200 μL in reduced SDS-PAGE sample buffer.

Storage: -20 °C

Storage Comment: -20 °C for long term storage

Target Details

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Alternative Name: Estrogen Receptor alpha (ESR1 Products)

Synonyms: LOC398734 Protein, AA420328 Protein, AU041214 Protein, ER-alpha Protein, ER[a] Protein, ERa Protein, ERalpha Protein, ESR Protein, Estr Protein, Estra Protein, Nr3a1 Protein, NR3A1 Protein, eralpha Protein, zfER[a] Protein, ER Protein, ESRA Protein, ESTRR Protein, Era Protein, akap12 Protein, cb27 Protein, esr1 Protein, fb72g12 Protein, id:ibd1202 Protein, sb:cb27 Protein, si:ch73-192g21.1 Protein, wu:fb72g12 Protein, wu:fc21c03 Protein, Esr Protein, RNESTROR Protein, ERALPHA Protein, er Protein, esr Protein, nr3a1 Protein, XER Protein, era Protein, esra Protein, ERbeta Protein, xesr-1 Protein, xlERalpha1 Protein, xlERalpha2 Protein, ESR1 Protein, estrogen receptor 1 L homeolog Protein, estrogen receptor 1 (alpha) Protein, estrogen receptor 1 Protein, A kinase (PRKA) anchor protein 12b Protein, esr1.L Protein, Esr1 Protein, ESR1 Protein, esr1 Protein, akap12b Protein

Background: Estrogen, a steroid hormone, is a key regulator of growth and differentiation in a broad range of target tissues and, it is also implicated in breast and endometrial cancer and osteoporosis. Like all steroid hormones, estrogen readily diffuses across cell membrane and binds to and activates estrogen receptors (α and β) which then up-regulate the expression of many genes. These receptors belong to the superfamily of nuclear receptors, more specifically to the family of steroid receptors that act as ligand-regulated transcription factors. The estrogen receptor (ER) is a key molecule for growth of breast cancers and is a successful target for treatment of breast cancers. Estrogen receptors mediate the pleiotropic effects of the steroid hormone estrogen on the growth, development and maintenance of a diverse range of tissues. Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins which play an important role in regulating mammary gland growth and differentiation. ER positive breast tumors show a more favorable response to anti-estrogen therapies.There are two mammalian ERs (ERα and Erβ) which exhibit modular structures characteristic of the nuclear receptor superfamily. ER alpha generally functions as an activator of transcription while ER beta functions as a repressor. Estrogen Receptor alpha is a 65 kDa protein and a member of the steroid family of nuclear receptors. Estrogen Receptor alpha is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change allowing dimerization and binding to estrogen response element sequences. When bound to DNA, Estrogen Receptor alpha positively or negatively regulates gene transcription. ERα is a key regulator of mitochondrial function and metabolism essential for energy-driven cellular processes in both normal and cancer cells. It also mediates bone-derived macrophage activation by proinflammatory cytokines. Loss of ERα accelerates the development of diethyl nitrosamine (DEN)-induced hepatocellular carcinoma by promoting hepatocyte necrosis over apoptosis in response to DEN due to a deficiency in energy production. Breast cancer therapy is directed at inhibiting the transcriptional potency of ERα, either by blocking estrogen production through aromatase inhibitors or anti estrogens that compete for hormone binding. The gene for Estra is present on chromosome 6q25.1

Molecular Weight: 71 kDa

UniProt: P03372

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly