Indian Hedgehog Protein (IHH)

Catalog No. ABIN2830462

This Recombinant Indian Hedgehog protein is produced in Escherichia coli (E. coli).

Quick Overview for Indian Hedgehog Protein (IHH) (ABIN2830462)

Target: Indian Hedgehog (IHH)

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Application: Functional Studies (Func)

Purity: >96 % as determined by SDS-PAGE and HPLC.

Product Details

Sequence: IIGPGRVVGS RRRPPRKLVP LAYKQFSPNV PEKTLGASGR YEGKIARSSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDRLNSLAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRAVDITTS DRDRNKYGLL ARLAVEAGFD WVYYESKAHV HCSVKSEHSA AAKTGG

Characteristics: Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by its ability to induce alkaline phosphatase production by C3H10T1/2(CCL-226) cells is 3.0-10 μg/mL.

Sterility: 0.2 μm filtered

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 20 mM PB, pH 7.4, 150 mM NaCl

Storage: -20 °C

Target Details

Target: Indian Hedgehog (IHH)

Alternative Name: IHH

Background: Relevance: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity). {ECO:0000250}.
Synonyms: IHH,

Molecular Weight: 19.8 kDa

UniProt: Q14623

Pathways: Hedgehog Signaling