MMP8 Protein (full length)

Catalog No. ABIN2965548

This Recombinant MMP8 protein is expressed in .

Quick Overview for MMP8 Protein (full length) (ABIN2965548)

Target: MMP8 (Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8))

Protein Type: Recombinant

Origin: Human

Host: Please inquire

Application: Activity Assay (AcA), Standard (STD)

Purity: > 90 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: full length

Characteristics: Recombinant Human Matrix Metalloproteinase-8

Application Details

Application Notes: Used as a standard for analyzing mammalian collagenase activity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The protein Solution (100 units/ml) in 0.05M Tris-HCl buffer, pH 7.6, containing 0.2M NaCl, 5mM CaCl2, 0.0025% NaN3 and 0.1% BSA.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details

Target: MMP8 (Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8))

Alternative Name: Matrix Metalloproteinase-8

Background: Matrix Metalloproteinase-8 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain having a molecular mass of 75 kDa. The MMP-8 is purified by proprietary chromatographic techniques. Introduction: Full-length recombinant human neutrophil pro-collagenase (MMP-8), latent form. Matrix metalloproteinase 8 (MMP-8), or neutrophil collagenase, degrades interstitial collagens, acting preferentially on collagen type I. Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils, which are the major cell type that expresses MMP-8. MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands (IgG or complement components) that release it through degranulation. Once released and activated through proteolytic or oxidative mechanisms, MMP-8 plays a major role in the connective tissue turnover that accompanies inflammatory processes. Synonyms: Neutrophil collagenase, EC 3.4.24.34, Matrix metalloproteinase-8, MMP-8, PMNL collagenase, PMNL-CL, HNC, CLG1.