HVEM Protein (AA 39-202) (His tag)
(1 reference)-
- Target See all HVEM (TNFRSF14) Proteins
- HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 39-202
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This HVEM protein is labelled with His tag.
- Application
- Functional Studies (Func)
- Sequence
- AA 39-202
- Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.2 kDa. The protein migrates as 33-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product TNFRSF14 Protein
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Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 39-202) protein (His tag)
TNFRSF14 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 39-202) protein (Fc Tag)TNFRSF14 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 38-200) protein (His-DYKDDDDK-Strep II Tag)TNFRSF14 Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 39-202) (Active) protein (Fc Tag)TNFRSF14 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (Active) protein (Fc Tag)TNFRSF14 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE Active
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) protein (His tag)TNFRSF14 Origin: Rhesus Monkey Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) protein (Fc Tag)TNFRSF14 Origin: Rhesus Monkey Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 38-283) protein (GST tag)TNFRSF14 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (Active) protein (His tag,Fc Tag)TNFRSF14 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 39-202) protein (hIgG-His-tag)TNFRSF14 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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: "Expression, purification, and efficient refolding of the extracellular domain of Escherichia coli-expressed signaling receptor herpesvirus entry mediator." in: Protein expression and purification, Vol. 164, pp. 105450, (2019) (PubMed).
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: "Expression, purification, and efficient refolding of the extracellular domain of Escherichia coli-expressed signaling receptor herpesvirus entry mediator." in: Protein expression and purification, Vol. 164, pp. 105450, (2019) (PubMed).
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- Target
- HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
- Alternative Name
- HVEM (TNFRSF14 Products)
- Target Type
- Viral Protein
- Background
- Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.
- Molecular Weight
- 19.2 kDa
- NCBI Accession
- NP_003811
- Pathways
- Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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