TNFSF9 Protein (AA 85-254, Soluble) (Fc Tag)
Quick Overview for TNFSF9 Protein (AA 85-254, Soluble) (Fc Tag) (ABIN5564465)
Target
See all TNFSF9 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 85-254, Soluble
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Purification tag / Conjugate
- This TNFSF9 protein is labelled with Fc Tag.
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Purpose
- Fc (human):CD137L, Soluble (human) (rec.)
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Specificity
- Binds to human CD137 receptor.
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Cross-Reactivity
- Human
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Characteristics
- The receptor-binding domain of human CD137L (aa 85-254) is fused at the N-terminus to the Fc portion of human IgG1.
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Endotoxin Level
- <0.01EU/μg purified protein (LAL test).
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Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 71-254), (Trimer) (Active) protein (Fc Tag,DYKDDDDK Tag)
TNFSF9 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 71-254), (Trimer) (Active) protein (Fc Tag,Biotin,DYKDDDDK Tag)TNFSF9 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 71-254), (Trimer) (Active) protein (His-DYKDDDDK Tag)TNFSF9 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 68-251) (Active) protein (hFc Tag)TNFSF9 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 50-254) protein (His-DYKDDDDK-Strep II Tag)TNFSF9 Origin: Human Host: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 99-330) protein (His tag,mFc Tag)TNFSF9 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (Active) protein (His tag)TNFSF9 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 99-330) protein (Fc Tag)TNFSF9 Origin: Mouse Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 71-254) protein (His-IF2DI Tag)TNFSF9 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 104-309) (Active) protein (Fc Tag)TNFSF9 Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Concentration
- 0.1 mg/mL
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Buffer
- Contains PBS.
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Handling Advice
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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Expiry Date
- 6 months
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- TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))
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Alternative Name
- :CD137L
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Background
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4-1BBL, TNFSF9
The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes and in T and B cell co-stimulation and modulation of the immune response.
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Molecular Weight
- ~46kDa (SDS-PAGE)
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UniProt
- P41273
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Pathways
- Activated T Cell Proliferation, Cancer Immune Checkpoints
Target
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