GM-CSF Protein
Quick Overview for GM-CSF Protein (ABIN5775831)
Target
See all GM-CSF (CSF2) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK
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Characteristics
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Purified recombinant Human GM-CSF protein
Expression System: E.coli
Bioactivity: The ED50 as determined by the dose-dependent stimulation of the proliferation of Mouse FDC-P1 cells is ? 0.05 ng/mL, corresponding to a specific activity of ? 2 x 10^7 units/mg. -
Endotoxin Level
- < 0.1 ng per μg (1 EU/μg).
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Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2) (AA 18-141) (Active) protein
CSF2 Origin: Mouse Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active
Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2) (Active) protein (His tag)CSF2 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE Active
Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2) (Active) proteinCSF2 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE Active
Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2) (AA 18-144) protein (Fc Tag)CSF2 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2) protein (His tag)CSF2 Origin: Rat Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2) (AA 1-144) protein (GST tag)CSF2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2) (AA 18-144) (Active) protein (His tag)CSF2 Origin: Human Host: HEK-293 Cells > 95 % AcA, CC Active
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Comment
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Biological activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of Mouse FDC-P1 cells is approx. 0.05 ng/mL, corresponding to a specific activity of approx. 2 x 10^7 units/mg.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute with distilled water to a concentration of 0.1-1.0 mg/mL.
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Buffer
- Lyophilized from 10 mM HoAc.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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- GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))
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Alternative Name
- GM-CSF
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Background
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GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and Mouse molecules are species-specific and exhibit no cross-species reactivity.
Alternative Names: CSF-2 protein, MGI-1GM protein, Granulocyte/Macrophage Colony-Stimulating Factor protein, pluripoietin-alpha protein, GM-CSF protein -
Molecular Weight
- 14.2 kDa
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Pathways
- JAK-STAT Signaling, Cellular Response to Molecule of Bacterial Origin
Target
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