RAB5 Protein

Catalog No. ABIN5776883

This Recombinant RAB5 protein is produced in Escherichia coli (E. coli).

Quick Overview for RAB5 Protein (ABIN5776883)

Target: RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))

Protein Type: Recombinant

Biological Activity: Active

Origin: Rat

Source: Escherichia coli (E. coli)

Purity: > 90 % (SDS-PAGE)

Product Details

Purpose: Rab5A, Ras-associated, small GTP-binding protein, rat, recombinant, E. coli

Biological Activity Comment: 100 pmol of protein can bind > 80 pmol of GDP.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied in 25 mM HEPES pH 7.240 mM NaCl2 mM MgCl210 μM GDP and 3 mM TCEP

Handling Advice: Please centrifuge briefly before opening (volume ≤2 ml).,avoid freeze/thaw cycles

Storage: -80 °C

Storage Comment: store at -80 °C avoid freeze/thaw cycles

Expiry Date: 12 months

Target Details

Target: RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))

Alternative Name: Rab5A

Background: Rab5A is a small GTPase that belongs to the Ras superfamily. Rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. The small Rab5A GTPase is localized to plasma membrane, clathrin coated vesicles, caveosomes and early endosomes. Rab5 is a key regulator of the early endocytic pathway and plays a role in early endosome fusion and caveolar vesicle targeting to early endosomes. Furtermore it is also implicated in EGF receptor activation and apoptotic cell engulfment.

Molecular Weight: 24 kDa

NCBI Accession: NP_073183

Pathways: Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity