CD147 Protein (AA 22-207) (hIgG-His-tag)

Catalog No. ABIN5855085

Product Details

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Protein Type: Recombinant

Protein Characteristics: AA 22-207

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This CD147 protein is labelled with hIgG-His-tag.

Application: SDS-PAGE (SDS)

Sequence: ADPAAGTVFT TVEDLGSKIL LTCSLNDSAT EVTGHRWLKG GVVLKEDALP GQKTEFKVDS DDQWGEYSCV FLPEPMGTAN IQLHGPPRVK AVKSSEHINE GETAMLVCKS ESVPPVTDWA WYKITDSEDK ALMNGSESRF FVSSSQGRSE LHIENLNMEA DPGQYRCNGT SSKGSDQAII TLRVRSHLAL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH

Purity: > 90% by SDS-PAGE

Endotoxin Level: < 1 EU per 1ug of protein (determined by LAL method)

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Target Details

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Alternative Name: CD147/BSG (BSG Products)

Background: BSG, also known as basigin isoform 2, is a type 1 transmembrane protein with various different N- and O- glycosylation that belongs to the immunoglobulin superfamily. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, it is thought also to play a role in intercellular recognition. This protein has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins and regulates several distinct functions, such as spermatogenesis, expression of the mono-carboxylate transporter and the responsiveness of lymphocytes. Also, it induces the production and release of matrix metalloproteinases in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Recombinant human BSG, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Molecular Weight: 47.5 kDa (428aa)

NCBI Accession: NP_940991

UniProt: P35613

Pathways: S100 Proteins