LRP6 Protein (AA 20-630) (Fc Tag)
Quick Overview for LRP6 Protein (AA 20-630) (Fc Tag) (ABIN6938849)
Target
See all LRP6 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 20-630
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Purification tag / Conjugate
- This LRP6 protein is labelled with Fc Tag.
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Endotoxin Level
- Less than 0.1 EU per μg by the LAL method.
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Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (AA 20-630) protein (mFc Tag)
LRP6 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE
Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (AA 20-1370) protein (His tag)LRP6 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
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Storage
- -20 °C
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- LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
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Alternative Name
- LRP-6
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Background
- LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.
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Molecular Weight
- 95.8 kDa
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NCBI Accession
- NP_002327
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Pathways
- WNT Signaling, Tube Formation
Target
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