GDF15 Protein (AA 197-308) (His tag)
Quick Overview for GDF15 Protein (AA 197-308) (His tag) (ABIN6952287)
Target
See all GDF15 ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 197-308
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Purification tag / Conjugate
- This GDF15 protein is labelled with His tag.
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Sequence
- AA 197-308
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Growth Differentiation Factor 15 (GDF15) (AA 197-308) (Active) protein (His tag)
GDF15 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE Active
Growth Differentiation Factor 15 (GDF15) (AA 197-308) (Active) protein (hFc Tag)GDF15 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Growth Differentiation Factor 15 (GDF15) (AA 197-308) (Active) protein (hFc Tag,Biotin)GDF15 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Growth Differentiation Factor 15 (GDF15) (AA 193-308) (Active) protein (His tag)GDF15 Origin: Cynomolgus Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE Active
Growth Differentiation Factor 15 (GDF15) (AA 197-307) (Active) protein (His tag)GDF15 Origin: Dog Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE Active
Growth Differentiation Factor 15 (GDF15) (AA 197-308) (Active) protein (hFc Tag,Biotin)GDF15 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Growth Differentiation Factor 15 (GDF15) (AA 189-303) (Active) protein (hFc Tag,Biotin)GDF15 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Growth Differentiation Factor 15 (GDF15) (AA 197-308) (Active) protein (Biotin,His-Avi Tag)GDF15 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE Active
Growth Differentiation Factor 15 (GDF15) (AA 31-308) protein (GST tag)GDF15 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 60 % ACN, 0.085 % TFA
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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- GDF15 (Growth Differentiation Factor 15 (GDF15))
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Alternative Name
- GDF-15
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Background
- Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1). Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1β, tumor necrosis factor α (TNF-α), interleukin 2, and macrophage colony-stimulating factor but not interferon γ, or lipopolysaccharide (LPS). It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF-15 level is linked with the progression and prognosis of the disease condition.
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Molecular Weight
- 14.2 kDa
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NCBI Accession
- NP_004855
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Pathways
- SARS-CoV-2 Protein Interactome
Target
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