VTCN1 Protein (AA 33-194) (Fc Tag)
Quick Overview for VTCN1 Protein (AA 33-194) (Fc Tag) (ABIN6964353)
Target
See all VTCN1 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 33-194
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Purification tag / Conjugate
- This VTCN1 protein is labelled with Fc Tag.
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Purpose
- Recombinant Human B7-H5 with C-terminal human Fc tag
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Specificity
- B7-H5(Phe33-Ala194) hFc(Glu99-Ala330)
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Characteristics
- Extracellular Domain Protein
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Purification
- Purified from cell culture supernatant by affinity chromatography
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V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 29-258) protein (His-Avi Tag)
VTCN1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 29-258) (Active) protein (Biotin,His-Avi Tag)VTCN1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 29-258) (Active) protein (His tag)VTCN1 Origin: Rhesus Monkey, Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 33-191) (Active) protein (His tag)VTCN1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 33-194) (Active) protein (hFc Tag)VTCN1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (Active) protein (Biotin)VTCN1 Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE. Active
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (Active) protein (His tag)VTCN1 Origin: Rhesus Monkey Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 29-256) protein (His tag)VTCN1 Origin: Mouse Host: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 31-258) protein (His-IF2DI Tag)VTCN1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 25-259) protein (His tag)VTCN1 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
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Application Notes
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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Comment
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please see Certificate of Analysis for specific instructions of reconstitution.
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))
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Alternative Name
- B7-H5
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Background
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B7-H5,B7H5,C10orf54,DD1alpha,Dies1,GI24,PD-1H,PP2135,SISP1,VISTA
Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).[UniProtKB/Swiss-Prot Function] -
Molecular Weight
- predicted molecular mass of 44.3 kDa after removal of the signal peptide.The apparent molecular mass of B7-H5-hFc is 55-70 kDa due to glycosylation.
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UniProt
- Q9H7M9
Target
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