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IL12A & IL27B (AA 20-189) (Active) protein (His tag)

Origin: Human, Rat Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active

Immobilized Human IL-23A & Rat IL-12B Heterodimer Protein, His Tag&Tag Free (3) at 5 μg/mL (100 μL/well) can bind Human IL-12 R beta 1, Fc Tag (ABIN6731330,ABIN6809859) with a linear range of 5-78 ng/mL (Routinely tested). (IL12A & IL27B (AA 20-189) (Active) protein (His tag))

Human IL-23A & Rat IL-12B Heterodimer Protein, His Tag&Tag Free on under reducing (R) condition. (IL12A & IL27B (AA 20-189) (Active) protein (His tag))

Immobilized Human IL-23 R, Fc Tag (ABIN6731281,ABIN6809891) at 5 μg/mL (100 μL/well) can bind Human IL-23A & Rat IL-12B Heterodimer Protein, His Tag&Tag Free (3) with a linear range of 0. (IL12A & IL27B (AA 20-189) (Active) protein (His tag))

3 images

Catalog No. ABIN6992356

Datasheet as PDF

Target

IL12A & IL27B

Protein Type

Recombinant

Biological Activity

Active

Protein Characteristics

AA 20-189
Origin
4

3

1
Human, Rat
Source
5

1
HEK-293 Cells

Purification tag / Conjugate

His tag

Purpose

Human IL-23 alpha & Rat IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified)

Purity

>90 % as determined by SDS-PAGE.

Endotoxin Level

Less than 1.0 EU per μg by the LAL method.
IL12A & IL27B (AA 22-196) (Active) protein (His tag)
Origin: Mouse Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Func Active

IL12A & IL27B (AA 20-189) (Active) protein (His tag)
Origin: Human, Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active

IL12A & IL27B (AA 20-189) (Active) protein (His tag)
Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active

IL12A & IL27B (AA 20-189) (Active) protein (His tag,AVI tag,Biotin)
Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active

IL12A & IL27B (AA 22-189) (Active) protein (His tag)
Origin: Mouse, Cynomolgus Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active

IL12A & IL27B (AA 20-189), (AA 23-328) protein (His tag)
Origin: Human Host: Human Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE. ELISA, MS, SDS, WB

Restrictions

For Research Use only
Format

Lyophilized

Buffer

PBS, pH 7.4

Storage

-20 °C
Target

IL12A & IL27B

Alternative Name

IL23A & IL12B

Background

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Molecular Weight

20.6 kDa, 35.9 kDa

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