IL12A & IL27B (AA 22-189) (Active) protein (His tag)

Catalog No. ABIN7013422

Product Details

Target: IL12A & IL27B

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 22-189

Origin: Mouse, Cynomolgus

Source: HEK-293 Cells

Purification tag / Conjugate: His tag

Characteristics: Cynomolgus IL-23 alpha & Mouse IL-12 beta Heterodimer Protein, His Tag&Tag Free

Purity: >90 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Target Details

Target: IL12A & IL27B

Alternative Name: IL23A & IL12B

Background: Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Molecular Weight: 20.3 kDa (IL23A) & 35.8 kDa (IL12B)