IL-2 Protein (His tag)

Catalog No. ABIN7125969

This Recombinant IL-2 protein is produced in HEK-293 Cells.

Quick Overview for IL-2 Protein (His tag) (ABIN7125969)

Target: IL-2 (IL2) (Interleukin 2 (IL2))

Protein Type: Recombinant

Origin: Cynomolgus

Source: HEK-293 Cells

Purity: >95 % as determined by SDS-PAGE.

Product Details

Purification tag / Conjugate: This IL-2 protein is labelled with His tag.

Purpose: Cynomolgus IL-2 Protein, His Tag

Sequence: Ala 21 - Thr 154

Characteristics: Cynomolgus IL-2, His Tag is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Thr 154 (Accession # Q29615-1).

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Application Notes: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 17.4 kDa. The protein migrates as 18 kDa under reducing (R) condition due to glycosylation.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Storage Comment: -20°C

Target Details

Target: IL-2 (IL2) (Interleukin 2 (IL2))

Alternative Name: IL-2

Background: Synonyms: IL2,TCGF,lymphokine,Interleukin 2,
Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56 % and 66 % aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit crossspecies activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self antigens", which could result in "autoimmunity". T-Regs do so by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.

Molecular Weight: 17.4 kDa

NCBI Accession: NP_001271628

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation