HPD Protein (His tag)
Quick Overview for HPD Protein (His tag) (ABIN7318119)
Target
See all HPD ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This HPD protein is labelled with His tag.
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Purpose
- Recombinant Human HPD/4HPPD Protein (His Tag)
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Sequence
- Met 1-Met393
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Characteristics
- Recombinant Human 4-Hydroxyphenylpyruvate Dioxygenase is produced by our E.coli expression system and the target gene encoding Met1-Met393 is expressed with a 6His tag at the N-terminus.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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4-Hydroxyphenylpyruvate Dioxygenase (HPD) (AA 1-393) protein (His-IF2DI Tag)
HPD Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
4-Hydroxyphenylpyruvate Dioxygenase (HPD) (AA 1-393) protein (GST tag)HPD Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
4-Hydroxyphenylpyruvate Dioxygenase (HPD) (Transcript Variant 2) protein (His tag)HPD Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
4-Hydroxyphenylpyruvate Dioxygenase (HPD) protein (Myc-DYKDDDDK Tag)HPD Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 50 mM NaCl, 1 mM DTT, 20 % Glycerol, pH 8.0.
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Preservative
- Dithiothreitol (DTT)
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Precaution of Use
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Expiry Date
- 6 months
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- HPD (4-Hydroxyphenylpyruvate Dioxygenase (HPD))
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Alternative Name
- HPD/4HPPD
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Background
- 4-Hydroxyphenylpyruvate Dioxygenase,4-Hydroxyphenylpyruvic Acid Oxidase,4HPPD,HPD,HPPDase,PPD,4-Hydroxyphenylpyruvate Dioxygenase (4HPPD) belongs to the 4HPPD family. 4HPPD is a key enzyme in the degradation of tyrosine, which catalyzes the second reaction in the catabolism of tyrosine the conversation of 4-hydroxyphenylpyruvate to homogentisate. 4HPPD exists in homodimer forms, which uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. When the active 4HPPD enzyme concentration is low in the human body, it results in high levels of tyrosine concentration in the blood, which can cause mild mental retardation at birth, and degradation in vision as a patient grows older.
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Molecular Weight
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Calculated MW: 47.1 kDa
Observed MW: 40-50 kDa
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Gene ID
- 3242
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UniProt
- P32754
Target
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