AKR1C2 Protein
Quick Overview for AKR1C2 Protein (ABIN7318143)
Target
See all AKR1C2 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human AKR1C2 Protein
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Sequence
- Met 1-Tyr323
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Characteristics
- Recombinant Human Aldo-Keto Reductase Family 1 Member C2 is produced by our E.coli expression system and the target gene encoding Met1-Tyr323 is expressed.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Aldo-keto Reductase Family 1, Member C2 (AKR1C2) (AA 1-323) protein (His tag)
custom-made AKR1C2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Aldo-keto Reductase Family 1, Member C2 (AKR1C2) (AA 1-256) protein (His-IF2DI Tag)AKR1C2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Aldo-keto Reductase Family 1, Member C2 (AKR1C2) (AA 224-323) protein (GST tag)AKR1C2 Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
Aldo-keto Reductase Family 1, Member C2 (AKR1C2) (AA 1-323) protein (GST tag)AKR1C2 Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
Aldo-keto Reductase Family 1, Member C2 (AKR1C2) (AA 1-323), (full length) protein (His-SUMO Tag)AKR1C2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
Aldo-keto Reductase Family 1, Member C2 (AKR1C2) protein (Myc-DYKDDDDK Tag)AKR1C2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, 1 mM DTT, pH 8.0.
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Preservative
- Dithiothreitol (DTT)
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Precaution of Use
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Expiry Date
- 6 months
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- AKR1C2 (Aldo-keto Reductase Family 1, Member C2 (AKR1C2))
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Alternative Name
- AKR1C2
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Background
- 2-Dihydrobenzene-1,2-Diol Dehydrogenase,3-Alpha-HSD3,Aldo-Keto Reductase Family 1 Member C2,Chlordecone Reductase Homolog HAKRD,DD-2,DD/BABP,DD2,Dihydrodiol Dehydrogenase 2,Dihydrodiol Dehydrogenase/Bile Acid-Binding Protein,Trans-1,Type III 3-Alpha-Hydro,Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation of the most potent androgen 5-α-Dihydrotestosterone (5-α-DHT) to 5-α-Androstane-3-α, 17-β-diol (3-α-diol).
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Molecular Weight
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Calculated MW: 36.7 kDa
Observed MW: 35 kDa
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Gene ID
- 1646
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UniProt
- P52895
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Pathways
- Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process
Target
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