APEX1 Protein (AA 2-318)
Quick Overview for APEX1 Protein (AA 2-318) (ABIN7318176)
Target
See all APEX1 ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 2-318
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Purpose
- Recombinant Human APE1/APE Protein
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Sequence
- Pro2-Leu318
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Characteristics
- Recombinant Human Apurinic-Apyrimidinic Endonuclease 1 is produced by our E.coli expression system and the target gene encoding Pro2-Leu318 is expressed.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) protein (GST tag)
APEX1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) protein (T7 tag)APEX1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 97-195) protein (His-IF2DI Tag)APEX1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) protein (His tag)APEX1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (Transcript Variant 1) proteinAPEX1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)APEX1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)APEX1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 10 mM HEPES, 100 mM KCl, 50 % Glycerol, pH 7.4.
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Preservative
- Without preservative
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Expiry Date
- 6 months
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- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
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Alternative Name
- APE1/APE
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Background
- AP Endonuclease 1,APE,APE-1REF-1,APE1,APEN,APEX,APEX Nuclease,APEX1,APX,Apurinic-Apyrimidinic Endonuclease 1,DNA-(Apurinic or Apyrimidinic Site) Lyase,HAP1,REF1,Redox Factor-1,Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
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Molecular Weight
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Calculated MW: 35.6 kDa
Observed MW: 40 kDa
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Gene ID
- 328
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UniProt
- P27695
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Pathways
- DNA Damage Repair, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
Target
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