CD147 Protein

Catalog No. ABIN7317976

This Recombinant CD147 protein is expressed in HEK-293 Cells.

Quick Overview for CD147 Protein (ABIN7317976)

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 97 % as determined by reducing SDS-PAGE.

Product Details

Purpose: Recombinant Human CD147/Basigin Protein

Sequence: Met 1-His 205

Characteristics: The mature form of human CD147 (NP_940991.1) extracellular domain (Met 1-His 205) with quinary-aa peptide (DDDDK) at the C-terminus was expressed and purified.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Alternative Name: CD147/Basigin

Background: 5F7,BSG,Basigin,CD147,Collagenase Stimulatory Factor,EMMPRIN,Extracellular Matrix Metalloproteinase Inducer,Leukocyte Activation Antigen M6,OK Blood Group Antigen,TCSF,Tumor Cell-Derived Collagenase Stimulatory Factor,CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.

Molecular Weight:

Calculated MW: 20.7 kDa

Observed MW: 35-38 kDa

Gene ID: 682

NCBI Accession: NP_940991

UniProt: P35613

Pathways: S100 Proteins