CRP Protein

Catalog No. ABIN7194465

This Recombinant CRP protein is produced in HEK-293 Cells.

Quick Overview for CRP Protein (ABIN7194465)

Target: CRP (C-Reactive Protein (CRP))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 90 % as determined by reducing SDS-PAGE.

Product Details

Purpose: Recombinant Human CRP/C-Reactive Protein

Sequence: Met 1-Pro224

Characteristics: A DNA sequence encoding the human CRP (P02741-1) (Met1-Pro224) was expressed and purified.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile 20 mM Tris, 0.2M NaCl, 5 mM CaCl2, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: CRP (C-Reactive Protein (CRP))

Alternative Name: CRP/C-Reactive

Background: C-Reactive Protein,CRP,PTX1,C-reactive protein (CRP) is synthesized by the liver in response to factors released by fat cells. It is a member of the pentraxin family of proteins. The levels of CRP rise in response to inflammation. Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monitor many human diseases. However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. CRP may also have pathogenic effects and the recent discovery of a prognostic association between increased CRP production and coronary atherothrombotic events is of particular interest.

Molecular Weight:

Calculated MW: 23 kDa

Observed MW: 26 kDa

Gene ID: 1401

UniProt: P02741

Pathways: Carbohydrate Homeostasis