Calmodulin 2 Protein (CALM2) (His tag)

Catalog No. ABIN7317378

This Recombinant Calmodulin 2 protein is produced in Escherichia coli (E. coli).

Quick Overview for Calmodulin 2 Protein (CALM2) (His tag) (ABIN7317378)

Target: Calmodulin 2 (CALM2)

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 85 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This Calmodulin 2 protein is labelled with His tag.

Purpose: Recombinant Human Calmodulin 2/CALM2 Protein (His Tag)

Sequence: Met 1-Lys149

Characteristics: A DNA sequence encoding the mature form of human CALM2 (P0DP24) (Met1-Lys149) was expressed with a polyhistide tag at the N-terminus.

Sterility: 0.2 μm filtered

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: Calmodulin 2 (CALM2)

Alternative Name: Calmodulin 2/CALM2

Background: CAMII,LQT15,PHKD,PHKD2,caM,Calmodulin 2, also known as CALM2, is a calmodulin. Calmodulin 2 mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). It is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Calmodulin 2 gene may be a genetic determinant of hip osteoarthritis (OA). OA is a degenerative disease characterized by gradual loss of articular cartilage and is a leading cause of disability in elderly populations. CALM2 was most abundantly expressed in articular chondrocytes and OA cartilage.

Molecular Weight:

Calculated MW: 18.7 kDa

Observed MW: 19-22 kDa

Gene ID: 805

UniProt: P0DP24

Pathways: RTK Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Cellular Glucan Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Phototransduction, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals, BCR Signaling