CPE Protein (His tag)

Catalog No. ABIN7318246

This Recombinant CPE protein is expressed in Human Cells.

Quick Overview for CPE Protein (His tag) (ABIN7318246)

Target: CPE (Carboxypeptidase E (CPE))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This CPE protein is labelled with His tag.

Purpose: Recombinant Human Carboxypeptidase E/CPE Protein (His Tag)

Sequence: Arg42-Ser453

Characteristics: Recombinant Human Carboxypeptidase E is produced by our Mammalian expression system and the target gene encoding Arg42-Ser453 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl,150 mM NaCl,1 mM ZnCl2,10 % Glycerol, pH 7.5.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: CPE (Carboxypeptidase E (CPE))

Alternative Name: Carboxypeptidase E/CPE

Background:

Background: The active form of CPE cleaves C-terminal amino acid residues of the peptide, and is thus involved in the biosynthesis of peptide hormones and neurotransmitters including insulin, enkephalin, etc. It is thought that membrane-associated CPE acts as a sorting receptor for targeting regulated secretory proteins which are mostly prohormones and neuropeptides in the trans-Golgi network of the pituitary and in secretory granules into the secretory pathway. Defects in this protein are implicated in type II diabetes due to impaired glucose clearance and insulin resistance.

Synonym: Carboxypeptidase E(CPE for short), Carboxypeptidase H, Enkephalin convertase, Prohormone-processing carboxypeptidase

Molecular Weight: 47.1 kDa

UniProt: P16870

Pathways: Peptide Hormone Metabolism, Synaptic Membrane