Ezrin Protein (EZR) (AA 1-586)
Quick Overview for Ezrin Protein (EZR) (AA 1-586) (ABIN7319618)
Target
See all Ezrin (EZR) ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 1-586
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Purpose
- Recombinant Human Ezrin/EZR Protein
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Sequence
- Met1-Leu586
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Characteristics
- Recombinant Human Ezrin is produced by our E.coli expression system and the target gene encoding Met1-Leu586 is expressed.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Ezrin (EZR) (AA 1-586) protein (GST tag)
EZR Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Ezrin (EZR) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)EZR Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Ezrin (EZR) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)EZR Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 10 mM HEPES, pH 7.4.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Expiry Date
- 6 months
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- Ezrin (EZR)
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Alternative Name
- Ezrin/EZR
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Background
- Cytovillin,EZR,Ezrin,VIL2,Villin-2,p81,Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskeletal structures to the plasma membrane. The N-terminal FERM domain strongly binds sodium-hydrogen exchanger regulatory factor (NHERF) proteins (involving long-range allostery). The C-terminal binds to actin, phosphatidylinositol bis-phosphate (PIP2) and membrane proteins like CD44 and ICAM-2. In epithelial cells, Ezrin is required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, Ezrin is required for normal macropinocytosis.
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Molecular Weight
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Calculated MW: 69.4 kDa
Observed MW: 80 kDa
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Gene ID
- 7430
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UniProt
- P15311
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Pathways
- Maintenance of Protein Location
Target
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