FETUB Protein (His tag)

Catalog No. ABIN7318470

This Recombinant FETUB protein is expressed in Human Cells.

Quick Overview for FETUB Protein (His tag) (ABIN7318470)

Target: FETUB (Fetuin B (FETUB))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This FETUB protein is labelled with His tag.

Purpose: Recombinant Human Fetuin-B/FETUB Protein (His Tag)

Sequence: Cys16-Pro382

Characteristics: Recombinant Human Fetuin B is produced by our Mammalian expression system and the target gene encoding Cys16-Pro382 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: FETUB (Fetuin B (FETUB))

Alternative Name: Fetuin-B/FETUB

Background:

Background: Fetuin-B is a member of the Fetuin family that is part of the Cystatin superfamily of Cysteine Protease inhibitors. It is reported that Fetuin-B is highly expressed in liver tissue, in tongue and placenta tissues. Fetuin-B is a paralogue of Fetuin-A. Fetuin-A and Fetuin-B display similarities and differences in their characteristics, however, they share only 20 % amino acid sequence identity. The amounts of Fetuin-B in human serum, unlike Fetuin-A, vary with gender and are higher in females than in males. Fetuin-B is an inhibitor of basic calcium phosphate precipitation but is less active than Fetuin-A. Fetuin-B expression is decreased in Fetuin-A deficient knock-out mice. The expression of Fetuin-B has been shown to be regulated by FXR (Farnesoid X Receptor), a nuclear receptor activated by bile acids. Evidence has shown that overexpression of Fetuin-B in skin squamous carcinoma cells suppresses tumor growth in nude mice. The function of Fetuin B is still not fully characterized.

Synonym: Fetuin-B, 16G2, Fetuin-Like Protein IRL685, Gugu, FETUB

Molecular Weight: 41.5 kDa

UniProt: Q9UGM5