FH Protein (AA 45-510)

Catalog No. ABIN7318507

This Recombinant FH protein is expressed in Escherichia coli (E. coli).

Quick Overview for FH Protein (AA 45-510) (ABIN7318507)

Target: FH (Fumarate Hydratase (FH))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 45-510

Purpose: Recombinant Human Fumarase/FH Protein

Sequence: Ala45-Lys510

Characteristics: Recombinant Human Fumarase is produced by our E.coli expression system and the target gene encoding Ala45-Lys510 is expressed.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, pH 8.0.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: FH (Fumarate Hydratase (FH))

Alternative Name: Fumarase/FH

Background: FH,FMRD,Fumarase,Fumarate Hydratase Mitochondrial,HLRCC,LRCC,MCL,MCUL1,Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase is thought to act as a tumor suppressor, which deficiency can lead to progressive encephalopathy, cerebral atrophy and development delay.

Molecular Weight:

Calculated MW: 50.2 kDa

Observed MW: 45 kDa

Gene ID: 2271

UniProt: P07954