IL1RAPL1 Protein (Fc Tag)

Catalog No. ABIN7196308

This Recombinant IL1RAPL1 protein is expressed in HEK-293 Cells.

Quick Overview for IL1RAPL1 Protein (Fc Tag) (ABIN7196308)

Target: IL1RAPL1 (Interleukin 1 Receptor Accessory Protein-Like 1 (IL1RAPL1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: HEK-293 Cells

Purity: > 95 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This IL1RAPL1 protein is labelled with Fc Tag.

Purpose: Recombinant Mouse IL-1R8/IL1RAPL1 Protein (Fc Tag)(Active)

Sequence: Met 1-Thr 357

Characteristics: A DNA sequence encoding the mouse IL1RAPL1 (P59823) extracellular domain (Met 1-Thr 357) was fused with the Fc region of human IgG1 at the C-terminus.

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind biotinylated human IL1α in functional ELISA.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IL1RAPL1 (Interleukin 1 Receptor Accessory Protein-Like 1 (IL1RAPL1))

Alternative Name: IL-1R8/IL1RAPL1

Background:

Background: Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a member of interleukin-1 receptor family. The protein structurally comprises three extracellular immunoglobulin domains, which presumably mediate binding of an as yet unidentified ligand, a transmembrane region, and an intracellular domain, which is likely to enable signalling via the NFkB pathway. The means of signalling is almost certain to be identical to that used by the IL1R family and the more distally related Toll protein. L1RAPL1 protein physically interacts via its 150 aa C-terminal domain with neuronal calcium sensor-1 (NCS-1), a protein widely expressed in neurons and the related chromaffin and PC12 cells. IL1RAPL1 is an integral membrane protein responsible for a nonsyndromic form of mental retardation (MR). It is suggested to affect human cognitive ability to some extent, especially the memory and concentration capability.

Synonym: 6330532G10Rik,C030039N24,IL1R8,IL1RAPL,MRX34,OPHN4,TIGIRR-2

Molecular Weight: 65 kDa

UniProt: P59823

Pathways: Synaptic Membrane, Growth Factor Binding