IL1RAPL1 Protein (AA 1-354) (His tag)

Catalog No. ABIN7196309

Product Details

Target: IL1RAPL1 (Interleukin 1 Receptor Accessory Protein-Like 1 (IL1RAPL1))

Protein Type: Recombinant

Protein Characteristics: AA 1-354

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This IL1RAPL1 protein is labelled with His tag.

Purpose: Recombinant Human IL-1R8/IL1RAPL1 Protein (aa 1-354, His Tag)

Sequence: Met 1-Leu 354

Characteristics: A DNA sequence encoding the human IL1R8 (NP_055086.1) extracellular domain (Met 1-Leu 354) was expressed with a C-terminal polyhistidine tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IL1RAPL1 (Interleukin 1 Receptor Accessory Protein-Like 1 (IL1RAPL1))

Alternative Name: IL-1R8/IL1RAPL1 (IL1RAPL1 Products)

Synonyms: Il1rapl Protein, 6330532G10Rik Protein, C030039N24 Protein, IL1R8 Protein, IL1RAPL Protein, MRX34 Protein, OPHN4 Protein, TIGIRR-2 Protein, MRX10 Protein, MRX21 Protein, wu:fi18g04 Protein, zgc:152866 Protein, interleukin 1 receptor accessory protein-like 1 Protein, interleukin 1 receptor accessory protein like 1 Protein, interleukin 1 receptor accessory protein-like 1a Protein, interleukin 1 receptor accessory protein-like 1b Protein, Il1rapl1 Protein, IL1RAPL1 Protein, il1rapl1a Protein, il1rapl1b Protein

Background:

Background: Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a member of interleukin-1 receptor family. The protein structurally comprises three extracellular immunoglobulin domains, which presumably mediate binding of an as yet unidentified ligand, a transmembrane region, and an intracellular domain, which is likely to enable signalling via the NFkB pathway. The means of signalling is almost certain to be identical to that used by the IL1R family and the more distally related Toll protein. L1RAPL1 protein physically interacts via its 150 aa C-terminal domain with neuronal calcium sensor-1 (NCS-1), a protein widely expressed in neurons and the related chromaffin and PC12 cells. IL1RAPL1 is an integral membrane protein responsible for a nonsyndromic form of mental retardation (MR). It is suggested to affect human cognitive ability to some extent, especially the memory and concentration capability.

Synonym: IL1R8,IL1RAPL,MRX10,MRX21,MRX34,OPHN4,TIGIRR-2

Molecular Weight: 40 kDa

NCBI Accession: NP_055086

Pathways: Synaptic Membrane, Growth Factor Binding