IL12B Protein
Quick Overview for IL12B Protein (ABIN7318099)
Target
See all IL12B ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human IL-12 p40/IL-12B Protein
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Sequence
- Ile23-Ser328
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Characteristics
- Recombinant Human Interleukin-12 subunit beta is produced by our Mammalian expression system and the target gene encoding Ile23-Ser328 is expressed.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Interleukin 12 beta (IL12B) (AA 23-328) protein (His tag)
IL12B Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 12 beta (IL12B) protein (His tag)IL12B Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Interleukin 12 beta (IL12B) (AA 229-328) protein (GST tag)IL12B Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 12 beta (IL12B) (AA 23-328) protein (His tag)IL12B Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
Interleukin 12 beta (IL12B) (AA 23-328) protein (His tag)IL12B Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 12 beta (IL12B) (AA 23-328) protein (Fc Tag)IL12B Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Interleukin 12 beta (IL12B) (AA 23-328), (full length) protein (GST tag)IL12B Origin: Human Host: Escherichia coli (E. coli) Recombinant 90 % ELISA
Interleukin 12 beta (IL12B) (AA 23-327), (full length) protein (His tag)IL12B Origin: Sheep Host: Yeast Recombinant > 90 % ELISA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- IL12B (Interleukin 12 beta (IL12B))
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Alternative Name
- IL-12 p40/IL-12B
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Background
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Background: Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor encoded by IL12B and a 35 kD subunit encoded by IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. It has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.
Synonym: Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40, NK cell stimulatory factor chain 2, NKSF2, IL12B, NKSF2
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Molecular Weight
- 34.6 kDa
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UniProt
- P29460
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Pathways
- JAK-STAT Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
Target
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