IL28B Protein (His tag)

Catalog No. ABIN7318666

This Recombinant IL28B protein is expressed in Human Cells.

Quick Overview for IL28B Protein (His tag) (ABIN7318666)

Target: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This IL28B protein is labelled with His tag.

Purpose: Recombinant Human IFN-λ3/IL-28B Protein (Human Cells, His Tag)(Active)

Sequence: Val22-Val196

Characteristics: Recombinant Human Interleukin-28B is produced by our Mammalian expression system and the target gene encoding Val22-Val196 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Human IL-28-His at 10μg/ml(100 μl/well) can bind Human IL-10RB-Fc(Cat: PKSH032564). The ED50 of Human IL-28-His is 0.37 ug/ml.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl,1 mM EDTA, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Alternative Name: IFN-lambda3/IL-28B

Background:

Background: Interleukin-28B, also known as Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, IFNL3, IFNL4, ZCYTO22 and IL28B, is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition, IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Synonym: Interleukin-28B, IL-28B, Cytokine Zcyto22, Interferon Lambda-3, IFN-Lambda-3, Interferon Lambda-4, IFN-Lambda-4, Interleukin-28C, IL-28C, IL28B, IFNL3, IFNL4, IL28C, ZCYTO22

Molecular Weight: 20.7 kDa

UniProt: Q8IZI9