IL28B Protein (AA 22-196) (His tag)

Catalog No. ABIN7318666

This Recombinant IL28B protein is expressed in HEK-293 Cells.

Quick Overview for IL28B Protein (AA 22-196) (His tag) (ABIN7318666)

Target: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 22-196

Purification tag / Conjugate: This IL28B protein is labelled with His tag.

Purpose: Recombinant Human IFN-λ3/IL-28B Protein (Human Cells, His Tag)

Sequence: Val22-Val196

Characteristics: Recombinant Human Interleukin-28B is produced by our Mammalian expression system and the target gene encoding Val22-Val196 is expressed with a 6His tag at the C-terminus.

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM EDTA, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Alternative Name: IFN-lambda3/IL-28B

Background: Cytokine Zcyto,ZCYTO,IFNL3,IFN-lambda-3,IFN-lambda-4,IL-28B,IL-28C,IL28B,IL28C,Cytokine Zcyto22,IFNL4,IFN-lambda 3,interferon lambda 3,Interferon Lambda-3,Interferon Lambda-4,Interleukin-28B,Interleukin-28C,ZCYTO22,Interleukin-28B, also known as Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, IFNL3, IFNL4, ZCYTO22 and IL28B, is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition, IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Molecular Weight:

Calculated MW: 20.7 kDa

Observed MW: 22 kDa

Gene ID: 282617

UniProt: Q8IZI9