METAP1 Protein (AA 1-386)
Quick Overview for METAP1 Protein (AA 1-386) (ABIN7319523)
Target
See all METAP1 ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 1-386
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Purpose
- Recombinant Human METAP1 Protein
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Sequence
- Met1-Phe386
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Characteristics
- Recombinant Human METAP1 is produced by our E.coli expression system and the target gene encoding Met1-Phe386 is expressed.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Methionyl Aminopeptidase 1 (METAP1) (AA 1-272) protein (GST tag)
METAP1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Methionyl Aminopeptidase 1 (METAP1) (AA 1-386) protein (His tag)METAP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Methionyl Aminopeptidase 1 (METAP1) (AA 1-386) protein (His-IF2DI Tag)METAP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Methionyl Aminopeptidase 1 (METAP1) protein (Myc-DYKDDDDK Tag)METAP1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 500 mM NaCl, 10 % Glycerol, pH 8.0.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Expiry Date
- 6 months
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- METAP1 (Methionyl Aminopeptidase 1 (METAP1))
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Alternative Name
- METAP1
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Background
- MAP 1,MAP1A,METAP1,MetAP 1,MetAP1A,Methionine aminopeptidase 1,Peptidase M 1,Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.
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Molecular Weight
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Calculated MW: 43.2 kDa
Observed MW: 38-50 kDa
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Gene ID
- 23173
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UniProt
- P53582
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Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
Target
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