NOV Protein (His tag)
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- Target See all NOV Proteins
- NOV (Nephroblastoma Overexpressed (NOV))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- Human Cells
- Purification tag / Conjugate
- This NOV protein is labelled with His tag.
- Purpose
- Recombinant Mouse NOV/CCN3 Protein (His Tag)
- Sequence
- Ser26-Ile354
- Characteristics
- Recombinant Mouse Nephroblastoma Overexpressed Gene is produced by our Mammalian expression system and the target gene encoding Ser26-Ile354 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product NOV Protein
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Nephroblastoma Overexpressed (NOV) (AA 1-357) protein (GST tag)
NOV Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Nephroblastoma Overexpressed (NOV) (AA 28-357) protein (His tag)NOV Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Nephroblastoma Overexpressed (NOV) (AA 32-131) protein (GST tag)NOV Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Nephroblastoma Overexpressed (NOV) (AA 32-357) protein (His tag)Crystallography grade NOV Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Nephroblastoma Overexpressed (NOV) (AA 22-354) protein (His tag)Crystallography grade NOV Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- NOV (Nephroblastoma Overexpressed (NOV))
- Alternative Name
- NOV/CCN3 (NOV Products)
- Synonyms
- CCN3 Protein, IBP-9 Protein, IGFBP-9 Protein, IGFBP9 Protein, NOVh Protein, nov-A Protein, xnov Protein, NovH Protein, C130088N23Rik Protein, nephroblastoma overexpressed Protein, nephroblastoma overexpressed L homeolog Protein, nephroblastoma overexpressed gene Protein, NOV Protein, nov.L Protein, Nov Protein
- Background
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Background: NOV, also called CCN3, is a secreted protein of CCN family members. CCN family members are highly conserved cysteine rich proteins sharing a common modular structure having 4 conserved domains, insulin-like growth factor-binding protein (IGFBP) domain, von Willebrand type C (VWC) domain, thrombospondin-1 (TSP-1) domain, and C-terminal (CT) domain (absent in CCN5). By specific interactions with these domains, CCN proteins modulate multiple signalling pathways including BMPs, Wnt, TGFs, Notch and integrins to regulate cell proliferation, differentiation, adhesion, migration, angiogenesis, and survival. CCN3 is firstly characterized as a promoter of progenitor activity of human hematopoietic stem cells, as knockdown of CCN3 can abrogate the function of primitive progenitors. Recent studies showed that CCN3 is also actively involved in the process of wound healing. CCN3 is highly expressed in granulation tissues of cutaneous wounds and capable of inducing synthetic responses of fibroblasts.
Synonym: Protein NOV homolog, NovH, CCN family member 3, Nephroblastoma-overexpressed gene protein homolog, Nov
- Molecular Weight
- 39.1 kDa
- UniProt
- Q64299
- Pathways
- Smooth Muscle Cell Migration, Growth Factor Binding
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