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Peroxiredoxin 1 Protein (PRDX1) (His tag)

PRDX1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7318889
  • Target See all Peroxiredoxin 1 (PRDX1) Proteins
    Peroxiredoxin 1 (PRDX1)
    Protein Type
    Recombinant
    Origin
    • 9
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 9
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This Peroxiredoxin 1 protein is labelled with His tag.
    Purpose
    Recombinant Human Peroxiredoxin 1/PRDX1 Protein (His Tag)
    Sequence
    Met 1-Lys199
    Characteristics
    Recombinant Human Peroxiredoxin-1 is produced by our E.coli expression system and the target gene encoding Met1-Lys199 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product PRDX1 Protein
  • Restrictions
    For Research Use only
  • Format
    Frozen, Liquid
    Buffer
    Supplied as a 0.2 μm filtered solution of PBS, 10 % glycerol, 0.1 mM DTT, pH 6.0.
    Storage
    -20 °C
    Storage Comment
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Target
    Peroxiredoxin 1 (PRDX1)
    Alternative Name
    Peroxiredoxin 1/PRDX1 (PRDX1 Products)
    Synonyms
    MSP23 Protein, NKEF-A Protein, NKEFA Protein, PAG Protein, PAGA Protein, PAGB Protein, PRX1 Protein, PRXI Protein, TDPX2 Protein, NkefA Protein, OSF-3 Protein, OSF3 Protein, Paga Protein, PrdxI Protein, PrxI Protein, TDX2 Protein, TPxA Protein, Tdpx2 Protein, prx1 Protein, Hbp23 Protein, MGC80194 Protein, MGC84820 Protein, PRDX1 Protein, msp23 Protein, nkefa Protein, pag Protein, paga Protein, pagb Protein, prx-1 Protein, prxi Protein, tdpx2 Protein, hm:zehl0637 Protein, zgc:110343 Protein, TPX-2 Protein, peroxiredoxin 1 Protein, peroxiredoxin 1 S homeolog Protein, peroxiredoxin-1 pseudogene Protein, PRDX1 Protein, Prdx1 Protein, prdx1.S Protein, prdx1 Protein, LOC100350232 Protein
    Background

    Background: Peroxiredoxin-1(PRDX1) contains 1 thioredoxin domain and belongs to the AhpC/TSA family. PRDX1 constitutively expressed in most human cells and it is induced to higher levels upon serum stimulation in untransformed and transformed cells. PRDX1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and play an important role in eliminating peroxides generated during metabolism. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. It may contribute to the antiviral activity of CD8(+) T-cells and have a proliferative effect in cancer development or progression.

    Synonym: Peroxiredoxin-1,Natural killer cell-enhancing factor A,NKEF-A,Proliferation-associated gene protein,PAG,Thioredoxin peroxidase 2,Thioredoxin-dependent peroxide reductase 2,PAGA, PAGB, TDPX2,MSP23,NKEF-A,NKEFA,PAG,PRX1,PRXI,TDPX2

    Molecular Weight
    25.3 kDa
    UniProt
    Q06830
    Pathways
    p53 Signaling, EGFR Signaling Pathway, CXCR4-mediated Signaling Events
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