Peroxiredoxin 1 Protein (PRDX1) (His tag)

Catalog No. ABIN7320235

This Recombinant Peroxiredoxin 1 protein is produced in Escherichia coli (E. coli).

Quick Overview for Peroxiredoxin 1 Protein (PRDX1) (His tag) (ABIN7320235)

Target: Peroxiredoxin 1 (PRDX1)

Protein Type: Recombinant

Origin: Mouse

Source: Escherichia coli (E. coli)

Purity: > 85 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This Peroxiredoxin 1 protein is labelled with His tag.

Purpose: Recombinant Mouse Peroxiredoxin 1/PRDX1 Protein (His Tag)

Sequence: Met 1-Lys 199

Characteristics: A DNA sequence encoding the mouse PRDX1 (P35700) (Met 1-Lys 199) was expressed, with a C-terminal polyhistidine tag.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, 10 % glycerol, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Peroxiredoxin 1 (PRDX1)

Alternative Name: Peroxiredoxin 1/PRDX1

Background:

Background: Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is induced to higher levels upon serum stimulation in untransformed and transformed cells. Peroxiredoxins (PRDXs) are a family of antioxidant enzymes that are also known as scavengers of peroxide in mammalian cells. The overexpression of Peroxiredoxin-1, which is one of the peroxiredoxins that is a ubiquitously expressed protein, was related to a poor prognosis in several types of human cancers. Peroxiredoxin-1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-1 Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. The reduced Peroxiredoxin-1 expression is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker.

Synonym: MSP23,NkefA,OSF-3,OSF3,PAG,Paga,PrdxI,prx1,PrxI,Tdpx2,TDX2,TPxA

Molecular Weight: 23.5 kDa

UniProt: P35700

Pathways: p53 Signaling, EGFR Signaling Pathway, CXCR4-mediated Signaling Events