STXBP3 Protein (His-GST)
Quick Overview for STXBP3 Protein (His-GST) (ABIN7317481)
Target
See all STXBP3 ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This STXBP3 protein is labelled with His-GST.
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Purpose
- Recombinant Human STXBP3/UNC-18C Protein (His & GST Tag)
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Sequence
- Met 1-Glu 592
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Characteristics
- A DNA sequence encoding the human STXBP3 (O00186-1) (Met 1-Glu 592) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Syntaxin Binding Protein 3 (STXBP3) (AA 1-592) protein (His tag)
custom-made STXBP3 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Syntaxin Binding Protein 3 (STXBP3) (AA 1-592) protein (His tag)custom-made STXBP3 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Syntaxin Binding Protein 3 (STXBP3) (AA 1-592) protein (GST tag)STXBP3 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Syntaxin Binding Protein 3 (STXBP3) protein (Myc-DYKDDDDK Tag)STXBP3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
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Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.5, 10 % glycerol
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Expiry Date
- 12 months
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- STXBP3 (Syntaxin Binding Protein 3 (STXBP3))
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Alternative Name
- STXBP3/UNC-18C
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Background
- MUNC18-3,MUNC18C,PSP,UNC-18C,Syntaxin-binding protein 3, also known as Platelet Sec1 protein, Protein unc-18 homolog 3, Protein unc-18 homolog C, Unc-18C, Unc18-3 and STXBP3, is a cytoplasm protein which belongs to theSTXBP/unc-18/SEC1 family. STXBP3 is expressed in cells that exhibit granule exocytosis, such as neutrophils, mast cells, platelets and endothelial cells. STXBP3, together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking / fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. STXBP3 participates in the consolidation and secretion of secondary and tertiary granules. STXBP3 contains one SEC1 domain. Phosphorylation at Ser129 may stimulate granule release. Human STXBP3 shares 90 % aa identity with mouse STXBP3. STXBP3 interacts with DOC2B, the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion. Interacts with STX4.
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Molecular Weight
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Calculated MW: 95.6 kDa
Observed MW: 95.6 kDa
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Gene ID
- 6814
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UniProt
- O00186
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Pathways
- Hormone Transport
Target
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