STXBP3 Protein
Quick Overview for STXBP3 Protein (ABIN7482130)
Target
See all STXBP3 ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Purpose
- Recombinant human Persephin protein
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Sequence
- ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG
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Specificity
- Toxin target: GFRα4 and RET receptor complex
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Biological Activity Comment
- Persephin promotes the survival of mesencephalic, dopaminergic and motor neurons1,2. The receptor for Persephin is a multicomponent complex composed of RET tyrosine kinase and the glycosyl-phosphatidylinositol (GPI)-anchored co-receptor GFR α1-α43,4.
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Syntaxin Binding Protein 3 (STXBP3) (AA 1-592) protein (His tag)
custom-made STXBP3 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Syntaxin Binding Protein 3 (STXBP3) (AA 1-592) protein (His tag)custom-made STXBP3 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Syntaxin Binding Protein 3 (STXBP3) (AA 1-592) protein (GST tag)STXBP3 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Syntaxin Binding Protein 3 (STXBP3) protein (Myc-DYKDDDDK Tag)STXBP3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Centrifuge the vial at 10,000 x g for 5 minutes before opening to ensure all material is collected at the bottom. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial and dissolve by gently tapping, tilting, or rolling the vial. Avoid vigorous vortexing, a brief, light vortex of 1-2 seconds is acceptable if necessary. Reconstitute in sterile, high-purity water at a concentration of at least 0.1 mg/mL. For long-term storage, aliquot the solution into small, single-use vials and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. For storage of dilute working solutions, we recommend adding a carrier protein (e.g., 0.1 % BSA) to your buffer to prevent material loss due to protein adsorption. Centrifuge all product preparations before use. It is recommended to prepare fresh working solutions just before use. Avoid multiple freeze-thaw cycles to maintain optimal biological activity.
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Buffer
- Lyophilized from PBS.
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Handling Advice
- Centrifuge the vial at 10,000 x g for 5 minutes before opening to ensure all material is collected at the bottom,Avoid multiple freeze-thaw cycles to maintain optimal biological activity,Avoid vigorous vortexing. protect from moisture
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Storage
- -20 °C
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Storage Comment
- The product is shipped as a lyophilized powder at room temperature. Upon receipt, store at -20°C and protect from moisture.
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- STXBP3 (Syntaxin Binding Protein 3 (STXBP3))
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Alternative Name
- PSP
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Background
- A recombinant human neurotrophic factor that promotes the survival of dopaminergic and motor neurons, primarily via the GFRα4 and RET receptor complex
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Molecular Weight
- 20.6 kDa (dimer)
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UniProt
- O60542
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Pathways
- Hormone Transport
Target
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