TLK2 Protein
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- Target See all TLK2 Proteins
- TLK2 (Tousled-Like Kinase 2 (TLK2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Baculovirus infected Insect Cells
- Purpose
- Recombinant Human TLK2/PKU-ALPHA Protein
- Sequence
- Leu 397-Asn772
- Characteristics
- A DNA sequence encoding the human TLK2 (Q86UE8-1) (Leu397-Asn772) was fused with two additional amino acids (Gly & Pro) at the N-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product TLK2 Protein
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Tousled-Like Kinase 2 (TLK2) (AA 1-750) (Active) protein (GST tag)
TLK2 Origin: Human Host: Insect cells (Sf21) Recombinant SDS, Func Active
Tousled-Like Kinase 2 (TLK2) (AA 1-126) protein (GST tag)TLK2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Tousled-Like Kinase 2 (TLK2) protein (GST tag,His tag)TLK2 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Tousled-Like Kinase 2 (TLK2) (AA 1-772) protein (Strep Tag)Crystallography grade TLK2 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Tousled-Like Kinase 2 (TLK2) (AA 1-718) protein (Strep Tag)Crystallography grade TLK2 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Tousled-Like Kinase 2 (TLK2) (Transcript Variant A) protein (Myc-DYKDDDDK Tag)TLK2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, 10 % glycerol, pH 8.0
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- TLK2 (Tousled-Like Kinase 2 (TLK2))
- Alternative Name
- TLK2/PKU-ALPHA (TLK2 Products)
- Synonyms
- tlk2 Protein, MGC149057 Protein, HsHPK Protein, PKU-ALPHA Protein, wu:fi16h09 Protein, wu:fi30g12 Protein, zgc:136697 Protein, 4933403M19Rik Protein, PKUalpha Protein, Tlk Protein, tousled like kinase 2 Protein, tousled-like kinase 2 Protein, tousled-like kinase 2 (Arabidopsis) Protein, tlk2 Protein, TLK2 Protein, Tlk2 Protein
- Background
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Background: Serine / threonine-protein kinase tousled-like 2; also known as PKU-alpha; Tousled-like kinase 2 and TLK2; is a nucleus protein which belongs to the protein kinase superfamily and Ser/Thr protein kinase family. The tousled-like kinases are an evolutionarily conserved family of proteins implicated in DNA repair; DNA replication and mitosis in metazoans and plants. Their absence from the yeasts and other eukaryotic 'microbes' suggests a specific role for them in the development of multicellular organisms. Tousled-like kinase 2 / TLK2 is widely expressed. It is present in fetal placenta; liver; kidney; pancreas; heart and skeletal muscle. It is also found in adult cell lines. Tousled-like kinase 2 / TLK2 contains one protein kinase domain. Tousled-like kinase 2 / TLK2 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.
Synonym: HsHPK;PKU-ALPHA
- Molecular Weight
- 43.6 kDa
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