HVEM Protein (Fc Tag)

Catalog No. ABIN7321001

This Recombinant HVEM protein is produced in Human Cells.

Quick Overview for HVEM Protein (Fc Tag) (ABIN7321001)

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Protein Type: Recombinant

Origin: Rhesus Monkey

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This HVEM protein is labelled with Fc Tag.

Purpose: Recombinant Rhesus macaque HVEM/TNFRSF14/CD270 Protein (Fc Tag)

Sequence: Pro37-Val203

Characteristics: Recombinant Rhesus macaque HVEM is produced by our Mammalian expression system and the target gene encoding Pro37-Val203 is expressed with a Fc tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Comment:

60 kDa

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Alternative Name: HVEM/TNFRSF14/CD270

Background:

Background: Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on na?ve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding.

Synonym: Tumor Necrosis Factor Receptor Superfamily Member 14, Herpes Virus Entry Mediator A, Herpesvirus Entry Mediator A, HveA, Tumor Necrosis Factor Receptor-Like 2, TR2, CD270, TNFRSF14, HVEA, HVEM

Molecular Weight: 44.7 kDa

NCBI Accession: XP_005545061

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints