CTLA4 Protein (His tag)
Quick Overview for CTLA4 Protein (His tag) (ABIN7321017)
Target
See all CTLA4 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purification tag / Conjugate
- This CTLA4 protein is labelled with His tag.
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Purpose
- Recombinant Cavia porcellus CTLA-4/CD152 Protein (His Tag)
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Sequence
- Ala37-Asp161
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Characteristics
- Recombinant Cavia porcellus CD152 is produced by our Yeast expression system and the target gene encoding Ala37-Asp161 is expressed with a 6His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- Immobilized Mouse B7-1-Fc(Cat: PKSM041366) at 1μg/ml(100 μl/well) can bind Cavia porcellus CTLA-4-His. The ED50 of Cavia porcellus CTLA-4-His is 0.17ug/ml .
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Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-161) protein (His tag,mFc Tag)
CTLA4 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-161) (Active) protein (Biotin,His-Avi Tag)CTLA4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-161) protein (Fc Tag)CTLA4 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 37-160) (Active) protein (His tag)CTLA4 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-162) (Active) protein (His tag)CTLA4 Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 37-162) (Active) protein (His tag)CTLA4 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 37-162) (Active) protein (Fc Tag,AVI tag,Biotin)CTLA4 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 37-161) protein (His-DYKDDDDK-Strep II Tag)CTLA4 Origin: Human Host: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (Active) protein (His tag)CTLA4 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE Active
Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-162) (Active) protein (Fc Tag)CTLA4 Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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Comment
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18-40 kDa
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
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Alternative Name
- CTLA-4/CD152
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Background
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Background: Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
Synonym: Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4
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Molecular Weight
- 14.1 kDa
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UniProt
- H0VUB1
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Pathways
- Cancer Immune Checkpoints
Target
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