IL7R Protein (AA 21-236) (His tag)
Quick Overview for IL7R Protein (AA 21-236) (His tag) (ABIN7274964)
Target
See all IL7R ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 21-236
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Purification tag / Conjugate
- This IL7R protein is labelled with His tag.
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Purpose
- Human IL-7R alpha/CD127 Protein
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Sequence
- Glu21-Gly236
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Characteristics
- Recombinant Human IL-7R alpha/CD127 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu21-Gly236.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1EU per μg by the LAL method.
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Biological Activity Comment
- The affinity constant of 22.66 nM as determined in SPR assay (Biacore T200). See testing image for detail.
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Interleukin 7 Receptor (IL7R) (AA 21-236) protein (Fc Tag)
IL7R Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 7 Receptor (IL7R) (AA 21-239) protein (Fc Tag)IL7R Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 7 Receptor (IL7R) (AA 21-236) protein (Fc Tag)IL7R Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 7 Receptor (IL7R) (AA 21-236) (Active) protein (Fc Tag)IL7R Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 7 Receptor (IL7R) (Active) protein (Fc Tag)IL7R Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE Active
Interleukin 7 Receptor (IL7R) (Active) protein (Fc Tag)IL7R Origin: Rat Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Interleukin 7 Receptor (IL7R) (AA 1-459) protein (GST tag)IL7R Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 7 Receptor (IL7R) protein (His tag)IL7R Origin: Mouse Host: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE
Interleukin 7 Receptor (IL7R) (AA 21-239) protein (hIgG-His-tag)IL7R Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
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Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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Expiry Date
- 12 months
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- IL7R (Interleukin 7 Receptor (IL7R))
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Alternative Name
- IL-7R alpha
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Background
- Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ultimately leading to the promotion of leukemia cell viability, cell cycle progression and growth.
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Molecular Weight
- 25.7 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
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UniProt
- P16871-1
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Pathways
- JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
Target
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