IL11RA Protein (AA 24-372) (His tag)

Catalog No. ABIN7275040

This Recombinant IL11RA protein is expressed in HEK-293 Cells.

Quick Overview for IL11RA Protein (AA 24-372) (His tag) (ABIN7275040)

Target: IL11RA (Interleukin 11 Receptor, alpha (IL11RA))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: HEK-293 Cells

Purity: > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC

Product Details

Protein Characteristics: AA 24-372

Purification tag / Conjugate: This IL11RA protein is labelled with His tag.

Purpose: Mouse IL-11R alpha Protein

Sequence: Ser24-Ala372

Characteristics: Recombinant Mouse IL-11R alpha Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser24-Ala372.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1 EU per μg by the LAL method.

Biological Activity Comment: Mouse IL-11R alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,The purity of Mouse IL-11R alpha is greater than 95% as determined by SEC-HPLC.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: IL11RA (Interleukin 11 Receptor, alpha (IL11RA))

Alternative Name: IL-11R alpha

Background: Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which triggered signal transduction either by exogenous recombinant human IL-11 or by autocrine production of IL-11 in cells cultured under hypoxic conditions.

Molecular Weight: 39.19 kDa. Due to glycosylation, the protein migrates to 48-58 kDa based on Bis-Tris PAGE result.

UniProt: Q64385

Pathways: JAK-STAT Signaling, Growth Factor Binding