CD33 Protein (CD33) (R119G) (Fc Tag)
Quick Overview for CD33 Protein (CD33) (R119G) (Fc Tag) (ABIN7316796)
Target
See all CD33 ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- R119G
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Purification tag / Conjugate
- This CD33 protein is labelled with Fc Tag.
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Purpose
- Human Siglec-3 / CD33 (R119G) Protein, Fc Tag
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Sequence
- Asp 18 - His 259
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Characteristics
- Human Siglec-3 (R119G), Fc Tag is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259 (Accession # AAH28152.1 (R119G).
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Endotoxin Level
- 1.0 EU per μg
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CD33 (CD33) (AA 18-259) protein (His-Avi Tag)
CD33 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE, > 95 % as determined by HPLC
CD33 (CD33) (AA 18-259) protein (Fc Tag)CD33 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD33 (CD33) (AA 18-259) protein (His-Avi Tag,Biotin)CD33 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
CD33 (CD33) (AA 18-240) protein (His tag)CD33 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD33 (CD33) (AA 17-248) protein (His tag)CD33 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD33 (CD33) (AA 18-259) protein (Fc-His Tag)CD33 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
CD33 (CD33) (AA 140-259) protein (Fc Tag)CD33 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
CD33 (CD33) (AA 18-240) protein (Fc Tag)CD33 Origin: Mouse Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
CD33 (CD33) (AA 1-364) protein (GST tag)CD33 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
CD33 (CD33) (AA 18-259) protein (His tag)CD33 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
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Comment
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This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 53.1 kDa. The protein migrates as 64-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
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Storage
- -20 °C
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Storage Comment
- -20°C
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- CD33
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Alternative Name
- Siglec-3
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Background
- Synonyms:CD33,SIGLEC3,gp67,Description:Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Ig-like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cD encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N--terminal Ig--like V--type domain, one Ig--like C2--type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
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Molecular Weight
- 53.1 kDa
Target
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