C5 Protein (Biotin,His-Avi Tag)
Quick Overview for C5 Protein (Biotin,His-Avi Tag) (ABIN7316821)
Target
See all C5 ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This C5 protein is labelled with Biotin,His-Avi Tag.
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Purpose
- Biotinylated Human Complement C5 Protein, His,Avitag™
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Sequence
- Gln 19 - Cys 1676
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Characteristics
- Biotinylated Human Complement C5, His,Avitag is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Cys 1676 (Accession # P01031-1).
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Endotoxin Level
- 1.0 EU per μg
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Complement Component 5 (C5) (AA 19-1676) protein (His tag)
C5 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Complement Component 5 (C5) proteinC5 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Complement Component 5 (C5) (AA 1550-1661) protein (GST tag)C5 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Complement Component 5 (C5) (AA 19-1680) (Active) protein (His tag)C5 Origin: Mouse Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Complement Component 5 (C5) (AA 19-1676) (Active) protein (His tag)C5 Origin: Cynomolgus Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Complement Component 5 (C5) (AA 24-1688) (Active) protein (His tag)C5 Origin: Rat Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Complement Component 5 (C5) (AA 19-1676) (Active) protein (His tag)C5 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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Comment
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This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 189.9 kDa. As a result of glycosylation, the protein migrates as 75 kDa, 120 kDa and 200 kDa under reducing (R) condition, and 200 kDa under non-reducing (NR) condition (SDS-PAGE).
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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Storage Comment
- -20°C
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- C5 (Complement Component 5 (C5))
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Alternative Name
- Complement C5
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Background
- Synonyms:Complement C5,C5,CPAMD4,Description:Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
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Molecular Weight
- 189.9 kDa
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NCBI Accession
- NP_001726
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Pathways
- Complement System, Carbohydrate Homeostasis
Target
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