APOE Protein
Quick Overview for APOE Protein (ABIN7482445)
Target
See all APOE ProteinsProtein Type
Origin
Source
Purity
Grade
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Purpose
- Human Apolipoprotein E / APOE4 Protein, Tag Free (MALS verified)
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Sequence
- Lys 19 - His 317
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Characteristics
- Human APOE4 Protein, Tag Free is expressed from human 293 cells (HEK293). It contains AA Lys 19 - His 317 (Accession # P02649-1 (C130R).
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Endotoxin Level
- 1.0 EU per μg
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Apolipoprotein E (APOE) (AA 19-311) protein (Fc Tag)
APOE Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Apolipoprotein E (APOE) (AA 19-317) protein (Fc Tag)APOE Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Apolipoprotein E (APOE) (AA 19-311) protein (His-IF2DI Tag)APOE Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Apolipoprotein E (APOE) protein (Myc-DYKDDDDK Tag)APOE Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Comment
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This protein carries no "tag". () The protein has a calculated MW of 34.4 kDa. The protein migrates as 34-41 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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Storage Comment
- -20°C
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- APOE (Apolipoprotein E (APOE))
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Alternative Name
- Apolipoprotein E
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Background
- APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.
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Molecular Weight
- 34.4 kDa
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Pathways
- Regulation of Cell Size, Lipid Metabolism
Target
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